ARC® Fertility Preservation

Practical Guidelines for Fertility Preservation in Cancer Patients

By S. Samuel Kim, MD ©
Center for Advanced Reproductive Medicine
University of Kansas Medical Center,
Center for Advanced Reproductive Medicine
10777 Nall Avenue, Suite 200
Overland Park, KS 66211

When the cancer is controlled, the later effect of treatment on quality of life, in particular fertility, can be a major issue for these young cancer survivors. Unfortunately, aggressive cancer treatments can cause gonadal failure. Indeed, most of the patients undergoing hematopoietic cell transplant will lose fertility due to high dose of chemotherapeutic agents and/or ionizing radiation. Where the risk of gonadal failure is high with chemotherapy and radiotherapy, it is wise to attempt to safeguard the fertility before treatment. To date, there are a few options for fertility preservation in female cancer patients including GnRHa administration with chemotherapy, freezing of embryos, oocytes, or ovarian tissue before chemotherapy and/or radiotherapy, transposition of the ovary before radiation, but most of theses options are